Today the world is really facing a huge problem of poorly water soluble drugs. Many methods are there for increasing the solubility, but nanotechnology is one of the most prominent and latest technologies. It deals with the nanoparticles (having high surface area) which are useful for increasing the solubility of poor water soluble drugs. Nanoparticles hold tremendous potential as an effective drug delivery system. This article discussed nanotechnology, its advantages, disadvantages, limitatations and developments for drug delivery. To overcome the problems of drug delivery of hydrophobic compounds, nanotechnology has gained interest in recent years. Important advances are being made in improving the bioavailability of hydrophobic compounds, so that promising candidate drugs need no longer be abandoned or have their development stalled by sub-optimal formulation. In addition to more conventional methods, tackling this problem has become one of the main applications of nanotechnology in drug delivery. This is also the most advanced approach commercially, as formulation scientists increasingly turn to a range of nanotechnology-based solutions to improve drug solubility and bioavailability. This paper highlights the properties of nanoparticles used in targeted drug delivery of poorly water soluble drug arteether. Nanoparticles exploit biological pathways to achieve payload delivery to various cellular and intracellular targets. Different nanodispersion systems such as micelles, nanoemulsions and nanosuspensions along with advantages and disadvantages are discussed here. Various nanoformulations represent promising means for delivering many bioactive agents, including peptide and protein drugs. The importance of these methods grew with the advancement in the understanding pharmacology of hydrophobic drugs as well as the ability to mass-produce these compounds. The polymers used here are non-toxic, non- immunogenic, non-antigenic, and highly soluble in water and FDA approved. In this article, we introduce the different strategies that have been developed with the use of different polymers such as polyethylene glycol (PEG) in delivery of hydrophobic compounds.
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